п»їProduct info: Diabetes
Avandamet (METFORMIN + ROSIGLITAZONE) tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes: Rosiglitazone maleate and metformin hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by increasing insulin sensitivity. Rosiglitazone improves glycemic control while reducing circulating insulin levels. Pharmacologic studies in animal models indicate that rosiglitazone improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. Rosiglitazone maleate is not chemically or functionally related to the sulfonylureas, the biguanides, or the О±-glucosidase inhibitors.
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п»їWhat should I avoid while taking Avandamet?
Avoid drinking alcohol while taking Avandamet. Alcohol lowers blood sugar and may increase the risk of lactic acidosis while you are taking this medicine.
Avandamet side effects
Stop using Avandamet and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness, weakness, headache, confusion, or problems with vision, speech, or balance;
feeling short of breath, swelling or rapid weight gain;
fever, chills, body aches, flu symptoms;
severe blistering, peeling, and red skin rash; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious Avandamet side effects may include:
sneezing, runny nose, cough or other signs of a cold;
back pain, joint or muscle pain; or
mild diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Avandamet?
You may be more likely to have hyperglycemia (high blood sugar) if you are taking Avandamet with other drugs that raise blood sugar:
diuretics (water pills);
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
seizure medicines (Dilantin and others); and
diet pills or medicines to treat asthma, colds or allergies.
You may be more likely to have hypoglycemia (low blood sugar) if you are taking Avandamet with other drugs that lower blood sugar:
some nonsteroidal anti-inflammatory drugs (NSAIDs);
aspirin or other salicylates (including Pepto-Bismol);
sulfa drugs (Bactrim, Cotrim, Septra, and others);
a monoamine oxidase inhibitor (MAOI);
beta-blockers (Tenormin and others); or
probenecid (Benemid).
Some medications may interact with Avandamet:
gemfibrozil (Gemcor);
rifampin (Rifater, Rifadin, Rimactane), vancomycin (Vancocin, Lyphocin);
nifedipine (Adalat, Procardia), procainamide (Procan, Pronestyl, Procanbid), quinidine (Cardioquin, Quinidex, Quinaglute);
cimetidine (Tagamet) or ranitidine (Zantac);
digoxin (Lanoxin); or
morphine (MS Contin, Kadian, Oramorph).
This list is not complete and there may be other drugs that can interact with Avandamet. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about Avandamet.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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